| SD Gundam Force | | | 8/1/2022 | $54.13 | $29.99 | $-24.14 | USA |
| Sea Trader: Rise of Taipan | | | 2/14/2021 | $4.70 | $19.00 | $14.30 | USA |
| Sea World Adventure Parks: Shamu's Deep Sea Adventures | | | 5/3/2019 | $2.76 | $4.53 | $1.77 | USA |
| Sega 3D Classics Collection | ✔ | ✔ | Unknown | Unknown | $25.94 | $0.00 | 3DS |
| Sega Arcade Gallery | | | 9/3/2021 | $9.05 | $27.01 | $17.96 | USA |
| Sega Rally Championship | | | 12/10/2021 | $173.15 | $113.09 | $-60.06 | USA |
| Sega Smash Pack | | | 3/5/2019 | $0.71 | $10.00 | $9.29 | USA |
| Serious Sam Advance | | | 5/6/2022 | $21.65 | $26.78 | $5.13 | USA |
| Shaman King: Master of Spirits | | | 4/9/2019 | $1.84 | $13.99 | $12.15 | USA |
| Shaman King: Master of Spirits 2 | | | 5/25/2022 | $40.86 | $56.30 | $15.44 | USA |
| Shantae and the Pirate's Curse | | | Unknown | Unknown | $0.00 | $0.00 | 3DSd |
| Shark Tale | | | 2/13/2019 | $1.22 | $5.22 | $4.00 | USA |
| Shark Tale and Shrek 2 | | | 10/28/2023 | $7.70 | $7.95 | $0.25 | USA Combo |
| Shaun Palmer's Pro Snowboarder | | | 9/3/2022 | $0.00 | $3.87 | $3.87 | USA |
| Shaun Palmer's Pro Snowboarder [USA-1] | | | 4/30/2019 | $1.47 | $3.87 | $2.40 | USA |
| Shaun Palmer's Pro Snowboarder [USA] | | | 10/2/2022 | $4.34 | $3.87 | $-0.47 | USA |
| Sheep | | | 8/15/2022 | $10.83 | $6.43 | $-4.40 | EUR |
| Shikakui Atama o Maru Kusuru Advance: Kanji Keisanhen | | | 6/25/2020 | $1.68 | $5.94 | $4.26 | JAP |
| Shinchan Aventuras En Cineland | | | 8/8/2024 | $28.86 | $37.72 | $8.86 | EUR |
| Shining Force: Resurrection of the Dark Dragon | | | 9/30/2021 | $64.14 | $54.50 | $-9.64 | USA |